Beware of Mixing PLLA with Hyaluronic Acid in Penis Fillers

In recent years, penis filler treatments have become increasingly popular for men seeking greater confidence and improved penile appearance.
However, not all fillers are the same — and mixing different types of fillers, such as PLLA (Poly-L-Lactic Acid) with Hyaluronic Acid (HA), can be dangerous and lead to serious complications.

Understanding the Difference Between PLLA and Hyaluronic Acid

Hyaluronic Acid (HA) fillers are made from a naturally occurring substance in the body. They are soft, smooth, and can be dissolved safely if needed.
This makes them the preferred and safest option for penis enlargement filler procedures.

By contrast, PLLA fillers (often used in facial treatments like Sculptra) are biostimulatory agents. They work by stimulating collagen production — not by adding direct volume. While this is useful in certain cosmetic areas, it is not suitable for penile tissue, where precision and safety are essential.

Why Mixing PLLA and HA Is Risky

Some non-specialist practitioners may attempt to mix or layer different filler types to achieve longer-lasting results.
This is highly unsafe for the following reasons:

• Inflammation and Lumps: PLLA can trigger a strong inflammatory response, particularly when mixed with HA.

• Hard Nodules and Irregularities: Collagen stimulation can cause hard lumps that are difficult to treat.

• Migration: PLLA does not stay where it is injected, increasing the risk of filler movement under the skin.

• Compromised Dissolvability: Unlike HA fillers, PLLA cannot be dissolved with hyaluronidase.

• Complications Requiring Surgery: In severe cases, surgical removal of the affected tissue may be required.

Choose a Specialist Clinic That Uses Safe, Approved Fillers

At Moorgate Andrology, we only use premium hyaluronic acid-based fillers that are medically approved and suitable for penile enlargement.
Our penis filler treatments are performed by specialist urologists trained in male genital aesthetics — ensuring the highest safety and precision.

If you’ve previously had penis filler treatment elsewhere and are unsure which product was used, you can learn more from our guide:
👉 Do You Know Which Penis Filler You Are Getting?

You can also read our article on Risks and Complications of Penis Fillers to understand more about how to stay safe.

The Takeaway

Mixing PLLA with Hyaluronic Acid in the penis is unsafe and should never be done.
Only trained medical specialists using approved HA fillers should perform these treatments.
If you are considering penis enlargement fillers or wish to correct a previous filler procedure, the team at Moorgate Andrology can help.